JUVÉDERM® is the #1 selling collection of hyaluronic acid fillers in the US. Each product in the JUVÉDERM® collection of fillers adds volume to a different area of the face to lift cheeks, smooth parentheses lines, or plump the lips. The results are subtle and long-lasting. The JUVÉDERM® collection of fillers is made from hyaluronic acid (HA). What’s interesting about HA is that it’s a natural substance in the skin that delivers nutrients, helps the skin retain moisture and softness, and adds volume.